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Haemophilia (0)

Haemophilia is a group of hereditary genetic disorders that impair the body's ability to control blood clotting or coagulation, which is used to stop bleeding when a blood vessel is broken. Haemophilia A (clotting factor VIII deficiency) is the most common form of the disorder, occurring at about 1 in 5,000–10,000 male births.Haemophilia B (factor IX deficiency) occurs at about 1 in about 20,000–34,000 male births.
Similarly to most recessive sex-linked, X chromosome disorders, hemophilia is more likely to occur in males rather than females. Female carriers may inherit the defective gene from either their mother, father, or it may be a new mutation.
Haemophilia lowers blood plasma clotting factor levels of the coagulation factors needed for a normal clotting process. Thus when a blood vessel is injured, a temporary scab does form, but the missing coagulation factors prevent fibrin formation, which is necessary to maintain the blood clot. In severe haemophiliacs even a minor injury could result in blood loss lasting days, weeks, or not ever healing completely. In areas such as the brain or inside joints, this can be fatal or permanently debilitating.